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'The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food is leading to a new understanding on metabolic disorders, including diabetes.
Scientists at the Salk Institute for Biological Studies, led by Ronald M. Evans, a professor in Salk’s Gene Expression Laboratory, showed that two cellular switches found on the nucleus of mouse cells, known as REV-ERB alpha and REV-ERB beta, are essential for maintaining normal sleeping and eating cycles and for metabolism of nutrients from food.
The findings, reported March 29 in Nature, describe a powerful link between circadian rhythms and metabolism and suggest a new avenue for understanding disorders of both systems, including jet lag, sleep disorders, obesity and diabetes.'
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